Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP9X | Q93008 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601271 | 0.77 | ALDH1A1 (0.37) | USP9XALDH1A1HPGDHTTPOLB | |
| SCHEMBL1601278 | 0.75 | USP9X (0.37) | USP9XALDH1A1HPGDHTTPOLB | |
| SCHEMBL1601272 | 0.73 | ALDH1A1 (0.44) | ALDH1A1HPGDHTTLMNAGAA | |
| SCHEMBL12709784 | 0.69 | SPPL2A (0.43) | ALDH1A1LMNAGAAMAPT | |
| SCHEMBL1602893 | 0.68 | ALDH1A1 (0.37) | ALDH1A1HPGDPOLBLMNAMAPT | |
| SCHEMBL12709726 | 0.66 | SPPL2A (0.42) | ALDH1A1LMNA | |
| SCHEMBL1601962 | 0.64 | BCHE (0.50) | — | |
| SCHEMBL1602099 | 0.63 | ALDH1A1 (0.39) | ALDH1A1HTTPOLBL3MBTL1 | |
| SCHEMBL5774206 | 0.61 | CSNK1E (0.34) | ALDH1A1 | |
| SCHEMBL1602156 | 0.61 | MLNR (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637518-A2 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |