Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15368480 | 0.83 | NPC1 (0.61) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL7941542 | 0.78 | MAPK10 (0.73) | KMT2AMEN1MAPK10GFERNPC1 | |
| SCHEMBL31220877 | 0.78 | MAPK10 (0.73) | KMT2AMEN1MAPK10GFERNPC1 | |
| SCHEMBL7982557 | 0.78 | NPC1 (0.52) | KMT2AMEN1MAPK10GFERNPC1 | |
| SCHEMBL7236672 | 0.78 | NPC1 (0.60) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL3953162 | 0.78 | NPC1 (0.55) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL10094589 | 0.78 | GRM5 (0.50) | GRM5KMT2AMEN1NPC1KDM4E | |
| SCHEMBL10094602 | 0.78 | MAPT (0.45) | GRM5KMT2AMEN1NPC1KDM4E | |
| SCHEMBL29783966 | 0.78 | IGF1R (0.55) | KMT2AMEN1NPC1KDM4EHTT | |
| SCHEMBL23319547 | 0.77 | GRM5 (0.54) | GRM5KMT2AMEN1MAPK10GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20060293503-A1 | Polyaminopyridines and method for producing same | SUMITOMO SEIKA CHEMICALS CO., LTD (JP) | 2006-12-28 | — | — | US | disclosed |
| EP-1669390-A1 | POLYAMINOPYRIDINES AND METHOD FOR PRODUCING SAME | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2006-06-14 | — | — | EP | disclosed |
| US-20060058178-A1 | Aromatic compounds containing nitrogen and p- functionalized amines, the production thereof and their use in catalytic reactions | DEGUSSA AG (DE) | 2006-03-16 | — | — | US | disclosed |
| EP-1446224-B1 | AROMATIC COMPOUNDS CONTAINING NITROGEN AND P-FUNCTIONALIZED AMINES, THE PRODUCTION THEREOF AND THEIR USE IN CATALYTIC REACTIONS | DEGUSSA (DE) | 2006-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058178-A1 | Aromatic compounds containing nitrogen and p- functionalized amines, the production thereof and their use in catalytic reactions | PAH, PNMT, TYR | GRM5 4477/4885KMT2A 943/4885MEN1 3253/4885 |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | GRM5 1/4885KMT2A 721/4885MEN1 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.