Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 4/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | ULK1 | O75385 | 1/20 | 0.54 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395330 | 0.87 | RAF1 (0.70) | RAF1NTRK1PDPK1LRRK2PSEN1 | |
| SCHEMBL1394995 | 0.87 | RAF1 (0.70) | RAF1NTRK1PDPK1LRRK2PSEN1 | |
| SCHEMBL7982420 | 0.83 | CASP3 (0.61) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7982417 | 0.83 | CASP3 (0.61) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL1395411 | 0.82 | LRRK2 (0.76) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL1395409 | 0.82 | LRRK2 (0.76) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7982403 | 0.81 | EGFR (0.58) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL7982402 | 0.81 | EGFR (0.58) | RAF1LRRK2PSEN1PSEN2APH1B | |
| SCHEMBL1395085 | 0.80 | PLK4 (0.79) | RAF1NTRK1LRRK2PSEN1PSEN2 | |
| SCHEMBL1395087 | 0.80 | PLK4 (0.79) | RAF1NTRK1LRRK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |