Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | ULK1 | O75385 | 1/20 | 0.50 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | CASP9 | P55211 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982403 | 1.00 | EGFR (0.58) | EGFRRAF1AURKAAURKBULK1 | |
| SCHEMBL7982417 | 0.91 | CASP3 (0.61) | RAF1AURKAAURKBULK1KIF15 | |
| SCHEMBL7982420 | 0.91 | CASP3 (0.61) | RAF1AURKAAURKBULK1KIF15 | |
| SCHEMBL5772971 | 0.81 | RAF1 (0.63) | RAF1ULK1KIF15PLK4PLK1 | |
| SCHEMBL1395190 | 0.80 | RAF1 (0.62) | EGFRRAF1AURKAAURKBKIF15 | |
| SCHEMBL5086209 | 0.80 | RAF1 (0.62) | EGFRRAF1AURKAAURKBKIF15 | |
| SCHEMBL6535504 | 0.78 | CASP3 (0.79) | EGFRCASP3CASP1CASP7CASP9 | |
| SCHEMBL24152475 | 0.77 | EGFR (0.53) | EGFRAURKAAURKBCASP3CASP1 | |
| SCHEMBL1395409 | 0.75 | LRRK2 (0.76) | EGFRRAF1ULK1KIF15PLK4 | |
| SCHEMBL1395411 | 0.75 | LRRK2 (0.76) | EGFRRAF1ULK1KIF15PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |