Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GCK | P35557 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796493 | 0.84 | KDM4E (0.57) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL27755107 | 0.84 | MEN1 (0.47) | HSD11B1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5772894 | 0.83 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL13805008 | 0.78 | ALDH1A1 (0.58) | ALDH1A1 | |
| SCHEMBL3603381 | 0.77 | MAPT (0.75) | HSD11B1MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL3596669 | 0.77 | HSD11B1 (0.76) | HSD11B1MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL3615504 | 0.76 | MAPT (0.65) | HSD11B1MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL3616478 | 0.75 | HSD11B1 (0.70) | HSD11B1MEN1KMT2ANAMPTSMN1; SMN2 | |
| SCHEMBL5746162 | 0.75 | MEN1 (0.52) | HSD11B1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5770063 | 0.75 | KDM4E (0.60) | MEN1KMT2ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735280-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | Kalypsys, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115983-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | KALYPSYS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |