Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5776800 | 0.97 | ADORA3 (0.39) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5775398 | 0.84 | ADORA3 (0.39) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5773897 | 0.83 | ADORA3 (0.38) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5774225 | 0.82 | NPY5R (0.50) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5776182 | 0.81 | HPGDS (0.40) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5774654 | 0.80 | NPY5R (0.41) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5777280 | 0.80 | HPGDS (0.39) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5775603 | 0.76 | ADORA3 (0.50) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5771758 | 0.74 | ADORA2A (0.48) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL5774543 | 0.74 | ADORA1 (0.48) | ADORA3ADORA1ADORA2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |