Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 6/20 | 0.38 |
| ▸ | F2R | P25116 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794868 | 0.83 | KDM4E (0.37) | SLC2A1KMT2A | |
| SCHEMBL5795813 | 0.80 | PTPN1 (0.34) | SLC2A1KMT2A | |
| SCHEMBL4691127 | 0.80 | SLC2A1 (0.44) | SLC2A1F2RPAX8 | |
| SCHEMBL23885288 | 0.72 | HDAC6 (0.43) | SLC2A1KMT2A | |
| SCHEMBL4694078 | 0.69 | KDM4E (0.42) | SLC2A1F2RPAX8 | |
| SCHEMBL5796107 | 0.68 | DHFR (0.36) | KMT2A | |
| SCHEMBL5798079 | 0.68 | CDK2 (0.39) | SLC2A1PAX8 | |
| SCHEMBL5796632 | 0.67 | SLC2A1 (0.42) | SLC2A1KMT2A | |
| SCHEMBL4689868 | 0.67 | SLC2A1 (0.41) | SLC2A1PAX8 | |
| SCHEMBL5799326 | 0.67 | FFAR1 (0.43) | PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628979-A1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101568-A1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | disclosed |