Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772205 | 0.76 | NPY5R (0.69) | NPC1RAB9ASMN1; SMN2KDM4ECCNE2 | |
| Hydrochloric Acid SCHEMBL5774401 | 0.75 | NPY5R (0.67) | NPC1RAB9ASMN1; SMN2KDM4ECCNE2 | |
| SCHEMBL14975199 | 0.74 | PRKCI (0.59) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL4417631 | 0.72 | PDPK1 (0.38) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL20665183 | 0.71 | KDM4E (0.44) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL7121617 | 0.71 | IKBKB (0.67) | NPC1RAB9ASMN1; SMN2IKBKBMAPT | |
| SCHEMBL2709303 | 0.70 | GAA (0.57) | RAB9ASMN1; SMN2CCNE2CDK4CCND1 | |
| SCHEMBL31202674 | 0.70 | GAA (0.57) | RAB9ASMN1; SMN2CCNE2CDK4CCND1 | |
| SCHEMBL20665179 | 0.69 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2KDM4ELMNA | |
| SCHEMBL5772086 | 0.69 | NPY5R (0.60) | NPC1RAB9APKMNPY5RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |