Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.37 |
| ▸ | KIT | P10721 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773424 | 0.98 | NPY5R (0.39) | NPY5RRAD51HRH4KITHRH3 | |
| SCHEMBL5772805 | 0.83 | HRH4 (0.39) | NPY5RHRH4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5778150 | 0.81 | HRH4 (0.38) | NPY5RHRH4MAPTKDM4EALDH1A1 | |
| SCHEMBL5772845 | 0.81 | NPY5R (0.41) | NPY5RKIT | |
| SCHEMBL5775406 | 0.81 | NPY5R (0.56) | NPY5RMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5772107 | 0.80 | XDH (0.43) | NPY5RKITKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL5773907 | 0.80 | NPY5R (0.55) | NPY5RMAPTL3MBTL1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5777029 | 0.79 | NPY5R (0.40) | NPY5RKIT | |
| Hydrochloric Acid SCHEMBL5774382 | 0.78 | XDH (0.41) | NPY5RKITKDM4EALDH1A1HPGD | |
| SCHEMBL5771896 | 0.77 | NPY5R (0.52) | NPY5RL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |