Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5778150 | 0.98 | HRH4 (0.38) | HRH4NPY5RKMOKDM4ENPC1 | |
| SCHEMBL5772845 | 0.86 | NPY5R (0.41) | NPY5RNPC1RAB9AADORA3ADORA1 | |
| Hydrochloric Acid SCHEMBL5777029 | 0.84 | NPY5R (0.40) | NPY5RNPC1RAB9AADORA3ADORA1 | |
| SCHEMBL5773685 | 0.83 | NPY5R (0.40) | HRH4NPY5RKDM4EMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL5773424 | 0.81 | NPY5R (0.39) | HRH4NPY5RKDM4EMAPTALDH1A1 | |
| SCHEMBL5772572 | 0.79 | KMO (0.43) | NPY5RKMONPC1RAB9AKMT2A | |
| SCHEMBL5772107 | 0.78 | XDH (0.43) | NPY5RKDM4EARALDH1A1HPGD | |
| SCHEMBL5775574 | 0.77 | KMO (0.44) | NPY5RKMOKDM4ENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5774382 | 0.77 | XDH (0.41) | NPY5RKDM4EARALDH1A1HPGD | |
| SCHEMBL5775406 | 0.76 | NPY5R (0.56) | NPY5RKDM4ERAB9AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |