Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577375 | 0.78 | CXCL8 (0.53) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL11515988 | 0.77 | CXCL8 (0.62) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL2690246 | 0.72 | CXCL8 (0.55) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL28809681 | 0.70 | CXCL8 (0.71) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL28160854 | 0.70 | KDM4E (0.46) | POLBKMT2ACYP2C9CYP2C19KCNH2 | |
| SCHEMBL11516024 | 0.69 | CXCL8 (0.58) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL12129515 | 0.69 | CXCL8 (1.00) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL3151521 | 0.69 | CXCL8 (1.00) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL3137707 | 0.69 | CXCL8 (1.00) | CXCL8KMT2AABCB11TTRCYP2C9 | |
| SCHEMBL576512 | 0.69 | CXCL8 (0.50) | CXCL8KMT2AABCB11TTRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | claimed |
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | disclosed |