Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774075 | 1.00 | DRD2 (0.40) | DRD2NR1H2GPR119ARDRD3 | |
| SCHEMBL5779420 | 0.84 | PLAU (0.44) | DRD2NR1H2GPR119ARKDM2B | |
| SCHEMBL18793347 | 0.81 | DRD2 (0.46) | DRD2NR1H2GPR119ARGHSR | |
| SCHEMBL29676890 | 0.81 | DRD2 (0.46) | DRD2NR1H2GPR119ARGHSR | |
| SCHEMBL5774300 | 0.80 | ESR2 (0.55) | DRD2NR1H2GPR119DRD3HDAC1 | |
| SCHEMBL5774304 | 0.80 | ESR2 (0.55) | DRD2NR1H2GPR119DRD3HDAC1 | |
| SCHEMBL5776208 | 0.80 | GHSR (0.46) | NR1H2GHSRHDAC1ESR2 | |
| SCHEMBL30878572 | 0.80 | GHSR (0.46) | NR1H2GHSRHDAC1ESR2 | |
| SCHEMBL5771882 | 0.78 | DRD2 (0.40) | DRD2DRD3 | |
| SCHEMBL5771876 | 0.78 | DRD2 (0.40) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |