Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.71 |
| ▸ | RAF1 | P04049 | 12/20 | 0.63 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.63 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | ARAF | P10398 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | MYOC | Q99972 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774827 | 1.00 | LRRK2 (0.71) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5776369 | 0.83 | LRRK2 (1.00) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5776367 | 0.83 | LRRK2 (1.00) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5775715 | 0.79 | LRRK2 (0.76) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5772153 | 0.79 | LRRK2 (0.72) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5772149 | 0.79 | LRRK2 (0.72) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL3753224 | 0.79 | RAF1 (0.73) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL3754416 | 0.79 | MAP1LC3B (0.88) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5774043 | 0.79 | MAP1LC3B (0.88) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 | |
| SCHEMBL5774039 | 0.79 | MAP1LC3B (0.88) | LRRK2RAF1PIK3C3MAP1LC3BPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |