Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.88 |
| ▸ | RAF1 | P04049 | 10/20 | 0.76 |
| ▸ | PLK4 | O00444 | 4/20 | 0.76 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | PLK1 | P53350 | 2/20 | 0.76 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.76 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.76 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.76 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.76 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.76 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.76 |
| ▸ | EGFR | P00533 | 1/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.76 |
| ▸ | ARAF | P10398 | 1/20 | 0.76 |
| ▸ | PIM1 | P11309 | 1/20 | 0.76 |
| ▸ | BRAF | P15056 | 1/20 | 0.76 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.76 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774043 | 1.00 | MAP1LC3B (0.88) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL5774039 | 1.00 | MAP1LC3B (0.88) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL22425999 | 0.93 | MAP1LC3B (1.00) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL5773323 | 0.89 | RAF1 (0.73) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL7980521 | 0.89 | RAF1 (0.73) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL1395360 | 0.88 | PLK4 (0.80) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL1395363 | 0.88 | PLK4 (0.80) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL30578769 | 0.88 | PLK4 (0.80) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL23964401 | 0.86 | RAF1 (0.73) | MAP1LC3BRAF1PLK4LRRK2MEN1 | |
| SCHEMBL1395354 | 0.86 | LRRK2 (1.00) | MAP1LC3BRAF1PLK4LRRK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | claimed |
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-11-25 | — | — | US | disclosed |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298376-A1 | USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, HTT, PARK7 | MAP1LC3B 187/4885RAF1 3935/4885PLK4 1784/4885 |
| US-20090264494-A1 | USE OF NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS | NLN, BDNF, HTT | MAP1LC3B 76/4885RAF1 3617/4885PLK4 1562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.