SCHEMBL5774900

SCHEMBL5774900

Cc1cc(-c2cnc(C(=O)CCCNC(=O)[CH]CC(F)(F)CCC(N)=O)o2)no1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FAAH O00519 5/20 0.36
CES1 P23141 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3873948 0.83
SCHEMBL5773806 0.82 FAAH (0.40) FAAHCES1
SCHEMBL5775485 0.74 SMN1; SMN2 (0.35)
SCHEMBL3873883 0.66 FAAH (0.33) FAAH
SCHEMBL5777473 0.63
SCHEMBL3871717 0.60 SMN1; SMN2 (0.34)
SCHEMBL3881018 0.56
SCHEMBL10095116 0.54 FAAH (0.74) FAAHCES1
SCHEMBL3876732 0.53 POLB (0.33) FAAH
SCHEMBL1471978 0.53 FAAH (1.00) FAAHCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1682524-A1 NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2006-07-26 EP claimed
WO-2005040142-A1 NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2005-05-06 WO claimed
EP-1682524-A1 NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS Aventis Pharmaceuticals, Inc. (US) 2006-07-26 EP disclosed
WO-2005040142-A1 NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2005-05-06 WO disclosed