Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777878 | 0.87 | MAPT (0.58) | MAPTHSP90AA1ESR2MTORDDB1 | |
| SCHEMBL6288255 | 0.87 | HSP90AA1 (0.51) | HSP90AA1CYP11B2KDM4E | |
| SCHEMBL21528039 | 0.79 | MAPT (0.63) | MAPTHSP90AA1ESR2DDB1CRBN | |
| SCHEMBL30805586 | 0.79 | MAPT (0.63) | MAPTHSP90AA1ESR2DDB1CRBN | |
| SCHEMBL21528090 | 0.78 | MAPT (0.62) | MAPTHSP90AA1ESR2DDB1CRBN | |
| SCHEMBL5774718 | 0.78 | MAPT (0.57) | MAPTHSP90AA1ESR2DDB1CRBN | |
| SCHEMBL1017921 | 0.78 | MAPT (0.77) | MAPTHSP90AA1MTORUSP2SMN1; SMN2 | |
| SCHEMBL21528088 | 0.76 | MAPT (0.68) | MAPTHSP90AA1 | |
| SCHEMBL30405628 | 0.76 | MAPT (0.68) | MAPTHSP90AA1 | |
| SCHEMBL30405728 | 0.76 | MAPT (0.68) | MAPTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |