Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774928 | 0.87 | MAPT (0.53) | MAPTHSP90AA1USP2SMN1; SMN2MTOR | |
| SCHEMBL30805586 | 0.84 | MAPT (0.63) | MAPTHSP90AA1ESR2NR1H2DDB1 | |
| SCHEMBL21528039 | 0.84 | MAPT (0.63) | MAPTHSP90AA1ESR2NR1H2DDB1 | |
| SCHEMBL21528090 | 0.83 | MAPT (0.62) | MAPTHSP90AA1ESR2NR1H2DDB1 | |
| SCHEMBL1017921 | 0.82 | MAPT (0.77) | MAPTHSP90AA1USP2SMN1; SMN2MTOR | |
| SCHEMBL18550268 | 0.78 | MAPT (0.59) | MAPTESR2NR1H2DDB1CRBN | |
| SCHEMBL30790206 | 0.78 | MAPT (0.57) | MAPTHSP90AA1USP2SMN1; SMN2MTOR | |
| SCHEMBL5774718 | 0.78 | MAPT (0.57) | MAPTHSP90AA1ESR2NR1H2DDB1 | |
| SCHEMBL4869824 | 0.78 | MAPT (0.67) | MAPTHSP90AA1ESR2NR1H2DDB1 | |
| SCHEMBL30378007 | 0.78 | MAPT (0.67) | MAPTHSP90AA1ESR2NR1H2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |
| US-6936619-B2 | Cardiovascular disorders; antilipemic agents; sexual disorders | PFIZER, INC. (US) | 2005-08-30 | — | — | US | disclosed |
| US-20040029859-A1 | Compounds useful in therapy | PFIZER INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029859-A1 | Compounds useful in therapy | ADRA1D, HSD3B1, PTGER1 | MAPT 4800/4885HSP90AA1 1452/4885USP2 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.