Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6288255 | 0.77 | HSP90AA1 (0.51) | HSP90AA1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5774928 | 0.71 | MAPT (0.53) | HSP90AA1KDM4EMTOR | |
| SCHEMBL15238568 | 0.68 | CYP1A2 (0.36) | KMT2A | |
| SCHEMBL30188618 | 0.65 | HSP90AA1 (0.50) | HSP90AA1KDM4EPOLBEPHX2HRH3 | |
| SCHEMBL7366975 | 0.62 | KDM4E (0.48) | KDM4EMEN1KMT2AALDH1A1ATM | |
| SCHEMBL17455035 | 0.59 | CNR2 (0.38) | HRH3ALOX15 | |
| SCHEMBL8267288 | 0.59 | GLA (0.56) | KDM4EMEN1KMT2AALDH1A1ATM | |
| SCHEMBL2932063 | 0.59 | DPP4 (0.46) | KDM4ESIGMAR1KMT2AALDH1A1POLB | |
| SCHEMBL18550257 | 0.58 | — | — | |
| SCHEMBL21201896 | 0.58 | SIGMAR1 (0.48) | KDM4ESIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |