Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576750 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL2687556 | 0.81 | PTGS2 (0.53) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL2687759 | 0.74 | PTGS2 (0.54) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL8814026 | 0.73 | PTGS1 (0.66) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL577062 | 0.73 | AKR1C3 (0.42) | PTGS2PTGS1SLC22A6 | |
| SCHEMBL2687418 | 0.71 | PTGS2 (0.60) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL2703769 | 0.70 | PTGS2 (0.58) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL1234209 | 0.69 | ESR1 (0.68) | ALDH1A1HSD17B10ESR1ESR2MEN1 | |
| SCHEMBL576614 | 0.69 | MAPT (0.60) | PTGS2PTGS1MAPTCXCR1CXCR2 | |
| SCHEMBL7042372 | 0.68 | MTNR1A (0.62) | KDM4EESR1ESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | disclosed |