Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482047 | 0.76 | HPGD (0.52) | HPGDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL11482052 | 0.76 | HPGD (0.52) | HPGDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL5771647 | 0.75 | HPGD (0.62) | HPGDMEN1KMT2ATSHRKDM1A | |
| SCHEMBL2686486 | 0.75 | HPGD (0.96) | HPGDMEN1KMT2ATSHRKDM1A | |
| SCHEMBL11475019 | 0.74 | HPGD (0.55) | HPGDMEN1KMT2AALDH1A1GAA | |
| SCHEMBL7182810 | 0.74 | SMN1; SMN2 (0.64) | HPGDMEN1KMT2ALMNAPOLB | |
| SCHEMBL9677283 | 0.74 | HPGD (1.00) | HPGDMEN1KMT2ATSHRKDM1A | |
| SCHEMBL7189572 | 0.72 | KMT2A (0.47) | HPGDMEN1KMT2ATSHRLMNA | |
| SCHEMBL5774256 | 0.72 | KMT2A (0.47) | HPGDMEN1KMT2ATSHRLMNA | |
| SCHEMBL6220956 | 0.71 | NR4A1 (0.53) | HPGDMEN1KMT2ATSHRCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |