Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MLYCD | O95822 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182897 | 0.84 | HPGD (0.50) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL5778017 | 0.81 | HPGD (0.47) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL5777755 | 0.80 | HPGD (0.66) | HPGDMEN1KMT2ATSHRLMNA | |
| SCHEMBL29209349 | 0.80 | HPGD (0.64) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL1942112 | 0.79 | ALOX5 (0.51) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL2686486 | 0.78 | HPGD (0.96) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL5775735 | 0.77 | MLYCD (0.42) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL9677283 | 0.76 | HPGD (1.00) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL5776155 | 0.75 | HPGD (0.58) | HPGDMEN1KMT2ATSHRMLYCD | |
| SCHEMBL23605283 | 0.75 | LIPE (0.46) | KDM1AALDH1A1GAATDP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211731-A1 | New substituted pyridine or piperidine compounds | LES LABORATORIES SERVIER (FR) | 2006-09-21 | — | — | US | disclosed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | METH-COHN OTTO (GB) | 2005-01-06 | — | — | US | disclosed |
| EP-1050531-B1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | SERVIER LAB (FR) | 2004-11-17 | — | — | EP | disclosed |
| US-6734196-B2 | ANALGESICS; COGNITION ACTIVATORS | LES LABORATOIRES SERVIER (FR) | 2004-05-11 | — | — | US | disclosed |
| US-6638946-B2 | 1-(4-bromophenyl)-2-(1-methyl-2-piperidinyl)-1-ethanone, for example; treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Korsakoff's disease and frontal lobe and subcortical dementias | LES LABORATOIRES SERVIER (FR) | 2003-10-28 | — | — | US | disclosed |
| US-20030181484-A1 | New substituted pyridine or piperidine compounds | METH-COHN OTTO (GB) | 2003-09-25 | — | — | US | disclosed |
| US-20030139408-A1 | Substituted pyridine or piperidine compounds | METH-COHN OTTO (GB) | 2003-07-24 | — | — | US | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6511992-B2 | For treating pain or memory deficiencies related to Alzheimer's disease and other neurodegenerative disorders associated with aging | LES LABORATORIES SERVIER (FR) | 2003-01-28 | — | — | US | disclosed |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-04-04 | — | — | US | disclosed |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-03-21 | — | — | US | disclosed |
| US-6323220-B1 | COGNITION ACTIVATORS AND TREATMENT OF NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| EP-1050531-A1 | Pyridine and piperidine derivatives for treating neurodegenerative diseases | ADIR ET COMPAGNIE (FR) | 2000-11-08 | — | — | EP | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181484-A1 | New substituted pyridine or piperidine compounds | CNR1, HRH4, OPRD1 | HPGD 320/4885MEN1 3393/4885KMT2A 2051/4885 |
| US-20060211731-A1 | New substituted pyridine or piperidine compounds | HRH3, P2RY1, CHRM1 | HPGD 560/4885MEN1 2723/4885KMT2A 1857/4885 |
| US-20030139408-A1 | Substituted pyridine or piperidine compounds | P2RY1, HRH3, CNR1 | HPGD 270/4885MEN1 2534/4885KMT2A 1762/4885 |
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | HRH3, HRH4, HRH1 | HPGD 173/4885MEN1 2244/4885KMT2A 1973/4885 |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | OPRD1, CNR1, HRH4 | HPGD 359/4885MEN1 3434/4885KMT2A 2175/4885 |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | CNR1, OPRD1, OPRK1 | HPGD 403/4885MEN1 3169/4885KMT2A 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.