Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482092 | 0.85 | L3MBTL1 (0.51) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD | |
| SCHEMBL11482052 | 0.77 | HPGD (0.52) | ALDH1A1HPGDHTTGAAMEN1 | |
| SCHEMBL11482047 | 0.77 | HPGD (0.52) | ALDH1A1HPGDHTTGAAMEN1 | |
| SCHEMBL2534411 | 0.76 | HPGD (1.00) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD | |
| SCHEMBL5949604 | 0.76 | SMN1; SMN2 (0.66) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD | |
| SCHEMBL11369868 | 0.76 | ALDH1A1 (1.00) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD | |
| SCHEMBL11475019 | 0.76 | HPGD (0.55) | ALDH1A1HPGDHTTGAAMEN1 | |
| SCHEMBL2535536 | 0.75 | HPGD (0.96) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD | |
| SCHEMBL5776155 | 0.74 | HPGD (0.58) | SMN1; SMN2ALDH1A1HPGDHTTGAA | |
| SCHEMBL28917005 | 0.74 | HPGD (0.70) | SMN1; SMN2L3MBTL1TP53ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |