Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 6/20 | 0.69 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811307 | 0.81 | LIMK1 (0.50) | LIMK1LMNACYP1A2CYP2C19KDM4E | |
| SCHEMBL716644 | 0.79 | LMNA (0.49) | LIMK1LMNAKDM4ENPC1L3MBTL1 | |
| SCHEMBL724156 | 0.76 | LIMK1 (0.45) | LIMK1LMNACYP2C19NPC1RAB9A | |
| SCHEMBL5775221 | 0.75 | LIMK1 (0.49) | LIMK1IKBKBCHUKPARP1LMNA | |
| SCHEMBL20723069 | 0.74 | LIMK1 (0.69) | LIMK1IKBKBCHUKKDM4EMKNK2 | |
| SCHEMBL19699885 | 0.74 | LIMK1 (0.49) | LIMK1LMNACYP3A4KDM4ECLK1 | |
| SCHEMBL13763321 | 0.73 | HSP90AA1 (0.48) | LIMK1LMNACYP3A4KDM4ECLK1 | |
| SCHEMBL30830385 | 0.73 | LIMK1 (0.55) | LIMK1IKBKBCHUKPARP1LMNA | |
| SCHEMBL29483598 | 0.73 | LIMK1 (0.68) | LIMK1IKBKBLMNAKDM4EGAA | |
| SCHEMBL2702750 | 0.73 | LIMK1 (0.68) | LIMK1IKBKBLMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660503-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005021553-A1 | NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS | PFIZER INC. (US) | 2005-03-10 | — | — | WO | disclosed |