Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GLRA3 | O75311 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1497963 | 0.70 | CDC25B (0.42) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| SCHEMBL29409962 | 0.70 | CDC25B (0.42) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| SCHEMBL1202545 | 0.69 | TRPA1 (0.38) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| Hydrochloric Acid SCHEMBL10860848 | 0.68 | KMT2A (0.40) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| Hydrochloric Acid SCHEMBL10863150 | 0.68 | KMT2A (0.40) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| Methane SCHEMBL28363844 | 0.68 | KMT2A (0.40) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| Potassium SCHEMBL31207020 | 0.68 | KMT2A (0.40) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| SCHEMBL3839654 | 0.67 | MEN1 (0.42) | MAPTKMT2AMEN1GAAEIF2AK2 | |
| SCHEMBL14362040 | 0.65 | PLAU (0.37) | KMT2AMAOAMAOB | |
| SCHEMBL5488008 | 0.65 | TRPA1 (0.35) | MAPTKMT2AMEN1GAAEIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105985347-B | A kind of benzo Macrocyclic lactams indole alkaloid and its purposes in anticomplement medicament is prepared | 复旦大学 | 2017-12-01 | — | — | CN | claimed |
| CN-105985347-A | Benzo-macrolactam indole alkaloid and application thereof in preparation of anti-complement medicines | 复旦大学 | 2016-10-05 | — | — | CN | claimed |
| CN-110256443-B | Indole derivative and preparation method thereof | 广州中医药大学(广州中医药研究院) | 2021-05-14 | — | — | CN | disclosed |
| CN-105985347-B | A kind of benzo Macrocyclic lactams indole alkaloid and its purposes in anticomplement medicament is prepared | 复旦大学 | 2017-12-01 | — | — | CN | disclosed |
| CN-105985347-A | Benzo-macrolactam indole alkaloid and application thereof in preparation of anti-complement medicines | 复旦大学 | 2016-10-05 | — | — | CN | disclosed |
| CN-105985347-A | Benzo-macrolactam indole alkaloid and application thereof in preparation of anti-complement medicines | 复旦大学 | 2016-10-05 | — | — | CN | disclosed |
| US-7144913-B2 | Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists | MERCK FROSST CANADA & CO. (CA) | 2006-12-05 | — | — | US | disclosed |
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |
| US-20040180934-A1 | Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists | MERCK FROSST CANADA LTD. (CA) | 2004-09-16 | — | — | US | disclosed |
| EP-1395590-A2 | DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-A]INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Merck Frosst Canada & Co. (CA) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094830-A2 | DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA & CO. (CA) | 2002-11-28 | — | — | WO | disclosed |
| EP-0445781-B1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC (US) | 1996-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180934-A1 | Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists | PTGDR, PTGDR2, PTGIR | MAPT 4139/4885KMT2A 3511/4885MEN1 3859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.