2-Aminopyridine

2-Aminopyridine

SCHEMBL5776523

Nc1ccccn1.Nc1ncccn1

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.84
NOS1 P29475 1/20 0.84
NOS2 P35228 1/20 0.84
PI4KA P42356 1/20 0.84
PI4K2B Q8TCG2 1/20 0.84
PI4K2A Q9BTU6 1/20 0.84
PI4KB Q9UBF8 1/20 0.84
HSP90AA1 P07900 4/20 0.63
GRM4 Q14833 1/20 0.45
KDM4E B2RXH2 6/20 0.45
ALOX15 P16050 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 2/20 0.43
CCR1 P32246 2/20 0.43
CCR5 P51681 2/20 0.43
CCR8 P51685 2/20 0.43
CYP1A2 P05177 1/20 0.43
POLB P06746 1/20 0.43
METAP1 P53582 1/20 0.43
BLM P54132 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Aminopyridine SCHEMBL2775240 0.92
2-Aminopyridine SCHEMBL9064720 0.92 NOS3 (1.00) NOS3NOS1NOS2PI4KAPI4K2B
2-Aminopyridine SCHEMBL17844 0.92
2-Aminopyridine SCHEMBL29392931 0.92
2-Aminopyridine SCHEMBL15012466 0.89
2-Aminopyridine SCHEMBL20496124 0.89
2-Aminopyridine SCHEMBL4938381 0.89
2-Aminopyridine SCHEMBL70318 0.89
2-Aminopyridine SCHEMBL8135890 0.89 NOS3 (0.94) NOS3NOS1NOS2PI4KAPI4K2B
2-Aminopyridine SCHEMBL2333406 0.89

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1670791-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF Amphora Discovery Corporation (US) 2006-06-21 EP claimed
US-20050085531-A1 Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof AGRIUS GROUP, LLC. 2005-04-21 US claimed
WO-2005033102-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF AMPHORA DISCOVERY CORPORATION (US) 2005-04-14 WO claimed
EP-1670791-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF Amphora Discovery Corporation (US) 2006-06-21 EP disclosed
US-20050085531-A1 Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof AGRIUS GROUP, LLC. 2005-04-21 US disclosed
WO-2005033102-A2 THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF AMPHORA DISCOVERY CORPORATION (US) 2005-04-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085531-A1 Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof ATP5MG, ATP5ME, ATP5MK NOS3 4288/4885NOS1 3805/4885NOS2 4068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.