Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777848 | 0.72 | ALDH1A1 (0.35) | LMNAALDH1A1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL5776814 | 0.71 | MAPT (0.35) | KDM4ELMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5776811 | 0.71 | MAPT (0.35) | KDM4ELMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8485089 | 0.68 | CTDSP1 (0.40) | KDM4ELMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4514590 | 0.68 | CTDSP1 (0.40) | KDM4ELMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4514586 | 0.68 | CTDSP1 (0.40) | KDM4ELMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6329164 | 0.67 | ALDH1A1 (0.42) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL13422055 | 0.67 | ALDH1A1 (0.42) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL13441754 | 0.66 | CTDSP1 (0.54) | KDM4ELMNAALDH1A1MAPTCYP1A2 | |
| SCHEMBL2432831 | 0.66 | CYP19A1 (0.51) | KDM4EALDH1A1MAPTTDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |