Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.34 |
| ▸ | TUBB | P07437 | 6/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.34 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776814 | 1.00 | MAPT (0.35) | MAPTPOLBTUBB4ATUBBTUBA3C | |
| SCHEMBL5778339 | 0.77 | GPBAR1 (0.34) | MAPTPOLBTSHRGAASMN1; SMN2 | |
| SCHEMBL2017595 | 0.76 | ALOX5 (0.39) | MAPTPOLBMAPK1GAASMN1; SMN2 | |
| SCHEMBL2017593 | 0.76 | ALOX5 (0.39) | MAPTPOLBMAPK1GAASMN1; SMN2 | |
| SCHEMBL5777846 | 0.72 | GABRA1 (0.40) | MAPTPOLBTSHRMAPK1GAA | |
| SCHEMBL5776817 | 0.71 | KDM4E (0.36) | MAPTPOLBTSHRMAPK1GAA | |
| SCHEMBL2018948 | 0.64 | SRD5A2 (0.46) | POLBLMNAKMT2AMEN1 | |
| SCHEMBL9466478 | 0.60 | KDM4E (0.56) | MAPTPOLBGAAALDH1A1CTDSP1 | |
| SCHEMBL21538783 | 0.60 | KDM4E (0.56) | MAPTPOLBGAAALDH1A1CTDSP1 | |
| SCHEMBL9466473 | 0.60 | KDM4E (0.56) | MAPTPOLBGAAALDH1A1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |