Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429499 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5779740 | 0.82 | ADRB2 (0.42) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6501448 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6504089 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6501442 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL27569468 | 0.82 | TYK2 (0.36) | KDM4EALDH1A1KDM1A | |
| SCHEMBL5779396 | 0.81 | ALB (0.35) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL6499194 | 0.72 | PIK3CA (0.34) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5777474 | 0.72 | KDM1A (0.43) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL5801851 | 0.70 | DPP4 (0.45) | KDM4EALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |