Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 3/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429499 | 0.90 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5777334 | 0.82 | RET (0.33) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL6501442 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL6504089 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL6501448 | 0.82 | KDM4E (0.34) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL6498293 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL5779396 | 0.79 | ALB (0.35) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL4306583 | 0.77 | KMT2A (0.60) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29576844 | 0.77 | KMT2A (0.60) | ADRB2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24137183 | 0.76 | KDM4E (0.44) | ADRB2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |