Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751255 | 0.89 | KCNH2 (0.38) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5764669 | 0.89 | KCNH2 (0.45) | KCNH2 | |
| SCHEMBL5750711 | 0.89 | KCNH2 (0.40) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5750809 | 0.88 | KCNH2 (0.38) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5747711 | 0.88 | KCNH2 (0.38) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL14573142 | 0.87 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL5746077 | 0.87 | KCNH2 (0.40) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5750830 | 0.87 | KCNH2 (0.38) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5750648 | 0.85 | KCNH2 (0.39) | KCNH2HTR1ADRD2HTR2AMEN1 | |
| SCHEMBL5776517 | 0.83 | KCNH2 (0.43) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343780-B1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF BACTERIAL INFECTIONS | SMITHKLINE BEECHAM PLC (GB) | 2006-09-20 | — | — | EP | claimed |