Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777533 | 1.00 | HDAC1 (0.41) | HDAC1GPR119KDM2BNR1H2NAMPT | |
| SCHEMBL7083279 | 0.85 | SLC6A2 (0.38) | GPR119KDM2BNR1H2NAMPTDRD2 | |
| SCHEMBL5774304 | 0.80 | ESR2 (0.55) | HDAC1GPR119NR1H2NAMPTDRD2 | |
| SCHEMBL5774300 | 0.80 | ESR2 (0.55) | HDAC1GPR119NR1H2NAMPTDRD2 | |
| SCHEMBL5774075 | 0.76 | DRD2 (0.40) | HDAC1GPR119KDM2BNR1H2DRD2 | |
| SCHEMBL5774074 | 0.76 | DRD2 (0.40) | HDAC1GPR119KDM2BNR1H2DRD2 | |
| SCHEMBL5772871 | 0.75 | DRD2 (0.44) | HDAC1DRD2ESR2 | |
| SCHEMBL5772873 | 0.75 | DRD2 (0.44) | HDAC1DRD2ESR2 | |
| SCHEMBL5776251 | 0.72 | SLC6A2 (0.42) | KDM2BNAMPT | |
| SCHEMBL5779179 | 0.72 | SLC6A2 (0.42) | KDM2BNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |