Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.67 |
| ▸ | BCR | P11274 | 9/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.67 |
| ▸ | PRKCA | P17252 | 2/20 | 0.65 |
| ▸ | KIT | P10721 | 7/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | ITK | Q08881 | 1/20 | 0.57 |
| ▸ | RAD52 | P43351 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775770 | 0.90 | PDGFRA (0.53) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4892544 | 0.87 | KIT (0.69) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL9677 | 0.80 | PDGFRA (1.00) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4903706 | 0.80 | PRKCA (0.70) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL15159937 | 0.80 | PRKCA (1.00) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL18814452 | 0.79 | PRKCA (0.81) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL12626986 | 0.79 | ABL1 (0.72) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL1656154 | 0.78 | PDGFRA (0.90) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL13492323 | 0.78 | PDGFRA (0.76) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL5776913 | 0.78 | PDGFRA (0.47) | ABL1PDGFRABCRPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395261-B1 | PYRIDYLPYRIMIDINE DERIVATIVES AS EFFECTIVE COMPOUNDS AGAINST PRION DISEASES | GPC BIOTECH AG (DE) | 2006-06-28 | — | — | EP | claimed |