Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.42 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289745 | 0.84 | ESR2 (0.53) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL6279147 | 0.83 | ALDH1A1 (0.44) | DRD2ABHD6 | |
| SCHEMBL5774734 | 0.83 | UCHL1 (0.53) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL29554603 | 0.83 | UCHL1 (0.53) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL29421814 | 0.82 | ESR2 (0.51) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL22530017 | 0.82 | ESR2 (0.51) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL5778372 | 0.82 | ESR2 (0.51) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL30606082 | 0.82 | NR1H2 (0.53) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL17687053 | 0.82 | NR1H2 (0.53) | UCHL1DDB1CRBNESR2SCN9A | |
| SCHEMBL5776971 | 0.81 | ESR2 (0.50) | UCHL1DDB1CRBNESR2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |