Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780883 | 0.91 | THRB (0.43) | KDM4EMDM2HSD17B10THRBHPGD | |
| SCHEMBL5782722 | 0.89 | HPGD (0.44) | KDM4EHSD17B10THRBHPGDALDH1A1 | |
| SCHEMBL5780819 | 0.88 | HPGD (0.49) | HSD17B10THRBHPGDALDH1A1TSHR | |
| SCHEMBL5779153 | 0.87 | HPGD (0.49) | KDM4EHSD17B10THRBHPGDALDH1A1 | |
| SCHEMBL5780598 | 0.86 | THRB (0.46) | HSD17B10THRBHPGDALDH1A1TSHR | |
| SCHEMBL5779552 | 0.86 | HPGD (0.44) | KDM4EHSD17B10THRBHPGDALDH1A1 | |
| SCHEMBL5778716 | 0.85 | KDM4E (0.41) | KDM4EMDM2HSD17B10THRBHPGD | |
| SCHEMBL5782481 | 0.85 | HSD17B10 (0.47) | KDM4EHSD17B10THRBHPGDALDH1A1 | |
| SCHEMBL4703390 | 0.83 | THRB (0.46) | HSD17B10THRBHPGDTSHRPTGER4 | |
| SCHEMBL5780879 | 0.83 | THRB (0.43) | KDM4EMDM2HSD17B10THRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194410-B1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2006-01-18 | — | — | EP | claimed |