Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482583 | 1.00 | ACE (0.57) | ACEATMHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1444662 | 1.00 | ACE (0.57) | ACEATMHSD17B10KDM4EALDH1A1 | |
| SCHEMBL2369794 | 0.98 | ACE (0.56) | ACEATMHSD17B10KDM4EALDH1A1 | |
| Methenamine SCHEMBL11110247 | 0.92 | ACE (0.51) | ACEATMHSD17B10KDM4EALDH1A1 | |
| SCHEMBL1652402 | 0.84 | ACE (0.54) | ACEATMHSD17B10ALDH1A1KMT2A | |
| SCHEMBL19253042 | 0.84 | ACE (0.54) | ACEATMHSD17B10ALDH1A1KMT2A | |
| SCHEMBL9409947 | 0.84 | ACE (0.54) | ACEATMHSD17B10ALDH1A1KMT2A | |
| SCHEMBL20718946 | 0.81 | ACE (0.53) | ACEATMHSD17B10KMT2ADPP4 | |
| SCHEMBL19075531 | 0.80 | ACE (0.51) | ACEATMHSD17B10ALDH1A1KMT2A | |
| SCHEMBL19075639 | 0.80 | ACE (0.51) | ACEATMHSD17B10ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-07-06 | — | — | US | disclosed |
| EP-1329451-B1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-6919349-B2 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES, INC. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES INC. (JP) | 2004-05-06 | — | — | US | disclosed |
| EP-1329451-A1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-20020091142-A1 | Alpha4beta1 and alpha4beta7 integrin inhibitors | COOKE NIGEL GRAHAM (US) | 2002-07-11 | — | — | US | disclosed |
| WO-2001068586-A2 | α4β1 AND α4β7 INTEGRIN INHIBITORS | NOVARTIS AG (CH) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190662-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | ACE 1083/4885ATM 4395/4885HSD17B10 2827/4885 |
| US-20020091142-A1 | Alpha4beta1 and alpha4beta7 integrin inhibitors | ITGB1, ITGB4, ITGB7 | ACE 3313/4885ATM 4530/4885HSD17B10 3132/4885 |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | VCAM1, ICAM1, SELL | ACE 303/4885ATM 2502/4885HSD17B10 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.