Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 11/20 | 0.45 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512863 | 0.95 | PTGS2 (0.44) | PTGS2KDM4EHTTPRKCIRNASEL | |
| SCHEMBL5781685 | 0.90 | MEN1 (0.49) | PTGS2HTTPRKCIRNASELPRKCZ | |
| SCHEMBL5780830 | 0.88 | PRKCI (0.53) | PTGS2KDM4EHTTPRKCIRNASEL | |
| SCHEMBL5777235 | 0.87 | PRKCI (0.58) | PTGS2PRKCIPRKCZ | |
| SCHEMBL5780486 | 0.85 | PDE5A (0.59) | PTGS2KDM4EHTTPRKCIPRKCZ | |
| SCHEMBL5802207 | 0.84 | RNASEL (0.49) | PTGS2HTTPRKCIRNASELPRKCZ | |
| SCHEMBL5122637 | 0.83 | SMN1; SMN2 (0.46) | PRKCIPDE5A | |
| SCHEMBL5802044 | 0.83 | PTGS2 (0.48) | PTGS2HTTPRKCIRNASELPRKCZ | |
| SCHEMBL8205517 | 0.82 | PRKCI (0.48) | KDM4EHTTPRKCI | |
| SCHEMBL5781751 | 0.82 | RNASEL (0.51) | PTGS2KDM4EHTTRNASELPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |