Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 5/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP4B1 | P13584 | 3/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.55 |
| ▸ | CYP3A5 | P20815 | 3/20 | 0.55 |
| ▸ | CYP2A7 | P20853 | 3/20 | 0.55 |
| ▸ | CYP3A7 | P24462 | 3/20 | 0.55 |
| ▸ | CYP2F1 | P24903 | 3/20 | 0.55 |
| ▸ | CYP2C18 | P33260 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.55 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.55 |
| ▸ | CYP4F8 | P98187 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839219 | 0.87 | CYP1A1 (0.55) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL11099027 | 0.86 | ABL1 (0.52) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL28824959 | 0.86 | ABL1 (0.52) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL1939273 | 0.82 | ALDH1A1 (0.31) | CYP3A4ALDH1A1 | |
| SCHEMBL17514933 | 0.82 | CYP1A1 (0.53) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL17514630 | 0.81 | CYP1B1 (0.52) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL17514703 | 0.81 | CYP1A1 (0.52) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL160135 | 0.79 | — | — | |
| SCHEMBL2753072 | 0.77 | ABL1 (0.57) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL2954516 | 0.75 | ALDH1A1 (0.79) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |