Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855585 | 0.81 | HRAS (0.50) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL5749627 | 0.73 | TOP1 (0.62) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL5745871 | 0.73 | TOP1 (0.62) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL9226064 | 0.69 | ALDH1A1 (0.34) | TOP1KDM4EMAPTMEN1CYP2C9 | |
| SCHEMBL4850168 | 0.68 | HRAS (0.49) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL14002833 | 0.66 | TOP1 (0.54) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL14441973 | 0.63 | CYP2C9 (0.43) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL1441399 | 0.63 | HDAC8 (0.47) | POLBKDM4EARMEN1CYP2C9 | |
| SCHEMBL5750357 | 0.62 | HRAS (0.58) | HRASESR1TOP1ESR2POLB | |
| SCHEMBL5748174 | 0.62 | TOP1 (0.62) | HRASESR1TOP1ESR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020446-B1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO LTD (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6300331-B1 | DRUGS AS ANTITUMOR AGENTS OR ANTICARCINOGENIC AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-09 | — | — | US | disclosed |
| EP-1020446-A1 | NAPHTHALIMIDOBENZAMIDE DERIVATIVES | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |