Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30305190 | 1.00 | PARP1 (0.36) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29816028 | 0.85 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL5775122 | 0.85 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL30548975 | 0.80 | CA12 (0.42) | KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL18306076 | 0.77 | PARP1 (0.32) | PARP1RAB9A | |
| SCHEMBL28871698 | 0.77 | POLB (0.36) | ALDH1A1LMNA | |
| SCHEMBL1568611 | 0.75 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL715561 | 0.75 | HSD17B10 (0.33) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30418799 | 0.75 | ADORA3 (0.32) | — | |
| SCHEMBL6061108 | 0.74 | PARP1 (0.36) | PARP1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107573340-A | The preparation and application of the miscellaneous pyridine compounds and their of the virtue of 2 carbamyl 4 | 江西科技师范大学 | 2018-01-12 | — | — | CN | claimed |
| CN-106831824-A | Pyrrolopyridines and its application containing naphthyridones structure | 江西科技师范大学 | 2017-06-13 | — | — | CN | claimed |
| EP-2521725-A1 | ARYLSULFONAMIDE PYRIDINE-PYRIDINONE DERIVATIVES, PREPARATION OF SAME, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-11-14 | — | — | EP | claimed |
| EP-1631570-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Abbott Laboratories (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2004083207-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ABBOTT LABORATORIES (US) | 2004-09-30 | — | — | WO | claimed |
| EP-3512849-A1 | 7-SUBSTITUTED 1-ARYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Aktiengesellschaft (DE) | 2019-07-24 | — | — | EP | disclosed |
| EP-3481823-A1 | 7-SUBSTITUTED 1-PYRIDYL-NAPHTHYRIDINE-3-CARBOXYLIC ACID AMIDES AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2019-05-15 | — | — | EP | disclosed |
| CN-109689656-A | 7-substituted 1-arylnaphthyridine-3-carboxamides and their use | 拜耳股份公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109689654-A | 7-substituted 1-pyridyl-naphthyridine-3-carboxamides and their use | 拜耳医药股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| US-20180297994-A1 | POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-10-18 | — | — | US | disclosed |
| CN-105985335-B | Hydroxamic acid compound, preparation method and its usage | 成都地奥九泓制药厂 | 2018-06-08 | — | — | CN | disclosed |
| CN-107949562-A | The positive allosteric modulators of muscarinic M2 acceptors | 拜耳制药股份公司 | 2018-04-20 | — | — | CN | disclosed |
| EP-3307741-A1 | POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR | Bayer Pharma Aktiengesellschaft (DE) | 2018-04-18 | — | — | EP | disclosed |
| CN-107573340-A | The preparation and application of the miscellaneous pyridine compounds and their of the virtue of 2 carbamyl 4 | 江西科技师范大学 | 2018-01-12 | — | — | CN | disclosed |
| CN-106831824-A | Pyrrolopyridines and its application containing naphthyridones structure | 江西科技师范大学 | 2017-06-13 | — | — | CN | disclosed |
| CN-105611927-A | Compounds for inhibiting drug-resistant strains of HIV-1 integrase | US HEALTH (US) | 2016-05-25 | — | — | CN | disclosed |
| EP-1631570-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Abbott Laboratories (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004083207-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ABBOTT LABORATORIES (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297994-A1 | POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC M2 RECEPTOR | CHRM2, CHRM1, CHRM3 | PARP1 3811/4885KDM4E 2769/4885ALDH1A1 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.