Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.74 |
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13195431 | 0.87 | GPR119 (0.74) | GPR119GPR183LMNAMAPTPOLB | |
| SCHEMBL15423133 | 0.87 | GPR119 (0.74) | GPR119GPR183LMNAMAPTPOLB | |
| SCHEMBL461984 | 0.85 | GPR119 (0.72) | GPR119GPR183LMNAMAPTCNR2 | |
| SCHEMBL19450725 | 0.85 | GPR119 (0.72) | GPR119GPR183LMNAMAPTPOLB | |
| SCHEMBL354846 | 0.85 | GPR119 (1.00) | GPR119GPR183LMNAMAPTCNR2 | |
| SCHEMBL28725071 | 0.84 | GPR119 (0.67) | GPR119GPR183LMNAMAPTCNR2 | |
| SCHEMBL14723499 | 0.83 | GPR119 (0.69) | GPR119GPR183LMNAMAPTCYP3A4 | |
| SCHEMBL11956913 | 0.83 | GPR119 (0.68) | GPR119GPR183LMNAMAPTCNR2 | |
| SCHEMBL19059470 | 0.83 | GPR119 (0.68) | GPR119GPR183CYP3A4CYP2C19 | |
| SCHEMBL470543 | 0.83 | GPR119 (0.73) | GPR119GPR183LMNAMAPTCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644375-A2 | FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2006-04-12 | — | — | EP | claimed |
| WO-2005007658-A2 | FUSED-ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |