Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777358 | 0.86 | AAK1 (0.36) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL5780662 | 0.84 | CDK4 (0.41) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5912676 | 0.83 | IMPDH2 (0.39) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5774837 | 0.77 | IMPDH2 (0.39) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5780289 | 0.76 | IMPDH2 (0.38) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5779104 | 0.75 | AAK1 (0.38) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5775263 | 0.75 | CDK4 (0.40) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5775549 | 0.71 | IMPDH2 (0.40) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5912811 | 0.71 | IMPDH2 (0.40) | AAK1NPC1RAB9APKMKDM4E | |
| SCHEMBL5778654 | 0.70 | CDK4 (0.40) | AAK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1612204-A1 | HYDRAZONE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-01-04 | — | — | EP | disclosed |