Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GLP1R | P43220 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703168 | 0.92 | THRB (0.48) | THRBRAB9AMAPTTSHRGLP1R | |
| SCHEMBL4702408 | 0.91 | THRB (0.44) | THRBRAB9AMAPTTSHRHSD17B10 | |
| SCHEMBL5778637 | 0.89 | THRB (0.46) | CRBNTHRBRAB9AMAPTTSHR | |
| SCHEMBL4703390 | 0.87 | THRB (0.46) | THRBRAB9AMAPTTSHRGLP1R | |
| SCHEMBL5781185 | 0.87 | THRB (0.48) | THRBGLP1RHSD17B10PTGER4 | |
| SCHEMBL5777980 | 0.86 | THRB (0.49) | CRBNTHRBHSD17B10PTGER4 | |
| SCHEMBL5779114 | 0.86 | THRB (0.47) | CRBNTHRBMAPTTSHRGLP1R | |
| SCHEMBL4703868 | 0.85 | THRB (0.44) | THRBRAB9AMAPTTSHRGLP1R | |
| SCHEMBL5783447 | 0.84 | HPGD (0.46) | CRBNTHRBTSHRGLP1RHSD17B10 | |
| SCHEMBL5783864 | 0.84 | THRB (0.46) | CRBNTHRBRAB9AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194410-B1 | BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2006-01-18 | — | — | EP | claimed |