Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | IRS1 | P35568 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779982 | 0.77 | IRS1 (0.51) | PTGS2PTGS1NR4A2MAPTKMT2A | |
| SCHEMBL8476489 | 0.75 | PTGS2 (0.51) | PTGS2PTGS1NR4A2MAPTKMT2A | |
| SCHEMBL5432044 | 0.74 | IRS1 (0.51) | PTGS2PTGS1NR4A2MAPTKMT2A | |
| SCHEMBL5418130 | 0.74 | KMT2A (0.58) | PTGS2PTGS1NR4A2MAPTKMT2A | |
| SCHEMBL6983193 | 0.74 | PTGS2 (0.67) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL5431928 | 0.74 | NOTUM (0.63) | PTGS2PTGS1NR4A2MAPTKMT2A | |
| SCHEMBL5428577 | 0.71 | PTGS2 (0.58) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL6979314 | 0.70 | PTGS2 (0.59) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL2277199 | 0.69 | PTGS2 (1.00) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL9396573 | 0.68 | HDAC6 (0.53) | MAPTKMT2AALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675585-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037271-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2005-04-28 | — | — | WO | disclosed |