Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | IRS1 | P35568 | 1/20 | 0.51 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979314 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL5431928 | 0.81 | NOTUM (0.63) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL5428577 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL2277199 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL5418130 | 0.79 | KMT2A (0.58) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL806849 | 0.79 | ACHE (0.66) | MAPTGABRA5ADORA1LMNAL3MBTL1 | |
| SCHEMBL1930084 | 0.77 | L3MBTL1 (0.67) | PTGS2PTGS1MAPTKMT2ANPSR1 | |
| SCHEMBL8565210 | 0.76 | GABRA5 (0.43) | PTGS2PTGS1MAPTKMT2AGABRA5 | |
| SCHEMBL4587731 | 0.75 | PTGS2 (0.80) | PTGS2PTGS1MAPTKMT2AMT-CO2 | |
| SCHEMBL30253815 | 0.75 | PTGS2 (0.63) | PTGS2PTGS1MAPTKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | PTGS2 266/4885PTGS1 398/4885MAPT 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.