SCHEMBL5780446

SCHEMBL5780446

CCOC(=O)CC1Cc2cc[c]cc2NC1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 5/20 0.36
MAPT P10636 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP1A2 P05177 1/20 0.36
KMT2A Q03164 2/20 0.36
MIF P14174 1/20 0.36
MEN1 O00255 1/20 0.36
PKM P14618 1/20 0.36
MAPK1 P28482 1/20 0.36
KDM4E B2RXH2 1/20 0.35
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
HSD17B1 P14061 1/20 0.34
OPRM1 P35372 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5775643 0.92 TSHR (0.46) TSHRHSD17B10ALDH1A1MAPTL3MBTL1
SCHEMBL5811684 0.89 HSD17B10 (0.41) TSHRHSD17B10ALDH1A1MIFMAPK1
SCHEMBL8304087 0.84 HSD17B10 (0.55) TSHRHSD17B10ALDH1A1MAPTL3MBTL1
SCHEMBL5779295 0.81 HTT (0.35) HSD17B10GAA
SCHEMBL7076747 0.81 HSD17B1 (0.45) TSHRHSD17B10ALDH1A1MAPTL3MBTL1
SCHEMBL5779777 0.79 HSD17B10 (0.43) TSHRHSD17B10ALDH1A1MIFMAPK1
SCHEMBL3285625 0.79 CREBBP (0.32)
SCHEMBL7073283 0.78 HSD17B1 (0.47) TSHRHSD17B10ALDH1A1MAPTCYP1A2
SCHEMBL1018625 0.77 TSHR (0.43) TSHRHSD17B10ALDH1A1MAPTL3MBTL1
SCHEMBL19055480 0.77 CYP1A2 (0.43) TSHRHSD17B10ALDH1A1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004089903-A9 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER LAMBERT CO (US) 2005-10-27 WO claimed
WO-2004089915-A1 PIPERAZINE DERIVATIVE RENIN INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-10-21 WO claimed
EP-1615890-A1 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER-LAMBERT COMPANY (US) 2006-01-18 EP disclosed
WO-2004089903-A9 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER LAMBERT CO (US) 2005-10-27 WO disclosed
WO-2004089903-A1 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER-LAMBERT COMPANY LLC (US) 2004-10-21 WO disclosed
WO-2004089915-A1 PIPERAZINE DERIVATIVE RENIN INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-10-21 WO disclosed