Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
| ▸ | PPIG | Q13427 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073283 | 0.87 | HSD17B1 (0.47) | TSHRHSD17B10CYP1A2KMT2AMEN1 | |
| SCHEMBL19055480 | 0.86 | CYP1A2 (0.43) | TSHRHSD17B10CYP1A2KMT2AMEN1 | |
| SCHEMBL8304087 | 0.83 | HSD17B10 (0.55) | TSHRHSD17B10CYP1A2KMT2AMEN1 | |
| SCHEMBL7075428 | 0.82 | BRD4 (0.42) | TSHRHSD17B10OPRM1 | |
| SCHEMBL1016536 | 0.82 | MAPT (0.43) | TSHRHSD17B10KMT2AMEN1GAA | |
| SCHEMBL7076747 | 0.80 | HSD17B1 (0.45) | TSHRHSD17B10KMT2AGAAHSD17B1 | |
| SCHEMBL17502915 | 0.79 | CA9 (0.36) | HSD17B10KMT2AMEN1GAAMAPT | |
| SCHEMBL5775643 | 0.79 | TSHR (0.46) | TSHRHSD17B10CYP1A2KMT2AMEN1 | |
| SCHEMBL3589075 | 0.78 | CA9 (0.37) | HSD17B10KMT2AMEN1GAAMAPT | |
| SCHEMBL5780446 | 0.77 | TSHR (0.44) | TSHRHSD17B10CYP1A2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |