Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 18/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4922241 | 0.85 | OPRD1 (0.70) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL474169 | 0.83 | OPRD1 (0.65) | OPRD1OPRM1OPRK1KCNH2 | |
| SCHEMBL5778658 | 0.81 | OPRM1 (0.68) | OPRD1OPRM1KCNH2 | |
| SCHEMBL5779863 | 0.81 | OPRD1 (0.58) | OPRD1OPRM1OPRK1KCNH2RIPK1 | |
| SCHEMBL5781527 | 0.80 | OPRD1 (0.67) | OPRD1OPRM1KCNH2 | |
| SCHEMBL5781201 | 0.80 | OPRD1 (0.64) | OPRD1OPRM1KCNH2 | |
| SCHEMBL5779506 | 0.80 | OPRM1 (0.49) | OPRD1OPRM1 | |
| SCHEMBL5780105 | 0.80 | OPRD1 (0.57) | OPRD1OPRM1OPRK1KCNH2RIPK1 | |
| SCHEMBL5779820 | 0.79 | OPRM1 (0.67) | OPRD1OPRM1KCNH2 | |
| SCHEMBL5781253 | 0.78 | OPRD1 (0.59) | OPRD1OPRM1OPRK1KCNH2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395575-B1 | 4-(PENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |
| US-6838468-B2 | 4-(phenyl-piperdin-4-ylidene methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2005-01-04 | — | — | US | disclosed |
| US-20040147553-A1 | 4-(phenyl-piperdin-4-ylidene methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147553-A1 | 4-(phenyl-piperdin-4-ylidene methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | HTR1D, OPRD1, HTR2C | OPRD1 2/4885OPRM1 5/4885OPRK1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.