Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 6/20 | 0.51 |
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30744099 | 1.00 | GRM5 (0.64) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL20301257 | 0.86 | MAOA (0.62) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL506960 | 0.73 | CYP2A6 (0.71) | CYP2A6KDM4EMAOAMAOBCA1 | |
| SCHEMBL28230155 | 0.73 | FTO (0.63) | GRM5FTOKDM4EMAOAMAOB | |
| SCHEMBL826634 | 0.73 | CYP2A6 (0.46) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL3681299 | 0.72 | FTO (0.61) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL2065762 | 0.72 | FTO (0.61) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL546240 | 0.72 | FTO (1.00) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL29799642 | 0.72 | FTO (1.00) | GRM5FTOCYP2A6KDM4EMAOA | |
| SCHEMBL903208 | 0.72 | FTO (0.61) | GRM5FTOKDM4EMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511734-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1511734-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003088903-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-10-30 | — | — | WO | disclosed |