Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975958 | 0.85 | L3MBTL1 (0.45) | OPRM1OPRD1OPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL4976000 | 0.72 | IDO1 (0.35) | ALDH1A1MEN1KMT2AOPRL1 | |
| SCHEMBL19285362 | 0.71 | CYP3A4 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL23670336 | 0.71 | CYP3A4 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL19285846 | 0.71 | CYP3A4 (0.36) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7247963 | 0.70 | RIPK1 (0.45) | L3MBTL1 | |
| SCHEMBL24312400 | 0.68 | CYP2D6 (0.38) | KMT2AL3MBTL1 | |
| SCHEMBL6158503 | 0.67 | CYP3A4 (0.37) | ALDH1A1MEN1KMT2AL3MBTL1POLB | |
| SCHEMBL8044669 | 0.67 | OPRL1 (0.56) | OPRM1OPRD1OPRK1ALDH1A1MEN1 | |
| SCHEMBL16225420 | 0.67 | CYP3A4 (0.34) | OPRM1OPRD1OPRK1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732928-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANOIC ACID COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS | Pfizer, Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092895-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANOIC ACID COMPOUNDS AS ORL1-RECEPTOR ANTAGONISTS | PFIZER JAPAN INC. (JP) | 2005-10-06 | — | — | WO | disclosed |