Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.53 |
| ▸ | MGAM | O43451 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SI | P14410 | 2/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | FASN | P49327 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.40 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.40 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440694 | 0.89 | PRKDC (0.55) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL14802143 | 0.87 | PRKDC (0.52) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5453418 | 0.87 | PRKDC (0.52) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5454434 | 0.85 | MGAM (0.63) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5441394 | 0.85 | PRKDC (0.50) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5444190 | 0.84 | PRKDC (0.56) | PRKDCMGAMGAAMAOAMAPT | |
| SCHEMBL5456126 | 0.83 | PRKDC (0.48) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL14802145 | 0.82 | PRKDC (0.47) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5783171 | 0.82 | PRKDC (0.49) | PRKDCMGAMGAASIMGAM2 | |
| SCHEMBL5782473 | 0.82 | PRKDC (0.49) | PRKDCGAAMAOAMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660473-A2 | XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS | Luitpold Pharmaceuticals, Inc. (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2004085418-A2 | XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS | LUITPOLD PHARMACEUTICALS, INC. (US) | 2004-10-07 | — | — | WO | disclosed |